Protein Crystallography Postdoctoral Fellow, UL, Ireland

[Aragao]

Postdoctoral Research Fellow - Macromolecular Crystallography
Membrane Structural and Functional Biology
University of Limerick, Ireland

The University of Limerick is inviting applications for the post of
Postdoctoral Research Fellow in the Membrane Structural and Functional
Biology Research Group. The major theme within the Group is structure
and function of membrane proteins by crystallographic means. Systems
under investigation include receptors, transducers, transporters,
respiratory complexes, and quorum sensing-related and biofilm forming
membrane proteins of Pseudomonas aeruginosa. Purified protein and in
meso-grown crystals of several targets are already in hand.

Required:

- A Ph.D. in macromolecular X-ray crystallography
- Experience and demonstrated success with macromolecular crystallization
- Experience and demonstrated mastery of all of the aspects of X-ray crystal structure determination
- Experience and demonstrated mastery of the latest crystallographic software
- Recent experience and demonstrated mastery of on-site data collection at a synchrotron X-ray source
- Availability and willingness to travel to synchrotrons and collaborators worldwide
- A commitment to quality and innovative research

Desirable:

- Expertise using and maintaining a home X-ray generator, diffractometer and cryo-system
- Expertise maintaining latest crystallographic software
- Expertise with low-resolution phasing and refinement
- Expertise with molecular dynamics simulations, electrostatic pKa and redox potential calculations, comparative modeling methods, and docking simulations
- Expertise collecting data with mini- or micro-X-ray beams (< 20 um)
- Expertise with small-angle X-ray scattering
- Experience over-expressing, purifying and crystallizing proteins, membrane proteins in particular

The candidate should be a highly motivated individual who enjoys working as part of a collaborative, multidisciplinary team. Strong leadership, communication
and teaching skills are decided assets.

Maximum available starting salary 47,606 Euro

The closing date for receipt of applications is Wednesday, 15th July
2009.

Further information for applicants and application material are
available online from: http://www.ul.ie/hrvacancies/ (Job ID: 004187)