Postdoctoral position in an international collaborative project
Project Title: Activation of TMEM16A to correct the transport defect in cystic fibrosis
Funding organization: Mukoviszidose Institut (Germany), Project Ref Number: 7207534
Research topic: The successful candidate will work in na international dynamic and enthusiastic team aiming to elucidate the molecular mechanisms underlying the genetic disease Cystic Fibrosis (CF) and the search for novel therapeutic compounds. His/her research will focus on the elucidation of membrane protein traffic by high-content screens, namely of normal and mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein and other Cystic Fibrosis related proteins.
Responsible PIs: Karl Kunzelmann, Dept Physiology, Univ. of Regensburg (Germany); Margarida Amaral, Fac of Sciences, Univ. of Lisboa (Portugal); Rainer Pepperkok, EMBL, Heidelberg (Germany).
Methods: Fluorescence microscopy and image analysis (as well as standard molecular biology and cell culture techniques).
Candidates: should be holders of a PhD in Biochemistry, Cell or Molecular Biology, Physiology or in a related area. Candidates with strong microscopy skills will be favoured. They should have a strong interest in studying disease mechanisms by cutting-edge approaches and enjoy working in an international stimulating research environment.
Place of work: Most of the work will be developed at EMBL-European Molecular Biology Laboratory, Heidelberg (Germany) but the candidates should also be prepared to travel among the collaborative labs.
Duration: This position is open for 1 year, starting in the beginning of October 2011, with possibility of 1 year renewal.
Monthly income: 2200-2400 Eur (after tax) depending on experience.
Applications: Applications should include a motivation letter, a CV with list of publications and references of two people well acquainted with the work of the candidate and should be sent no later than 30 Sept 2011 to: Prof Karl Kunzelmann (karl.kunzelmann@vkl.uni-regensburg.de) or to Prof. Dr. M. Amaral (mdamaral@fc.ul.pt)