DIVISION OF BIOLOGICAL CHEMISTRY AND MOLECULAR MICROBIOLOGY
A number of posts are available within Medicinal Chemistry at the University of Dundee.
The posts are based within the James Black Centre, a new building completed in 2005, part of the University’s internationally respected College of Life Sciences. Appointees will work as a part of a multi-disciplinary drug discovery team, and be expected to design and synthesise potential drug candidates. All posts represent a unique opportunity to work on drug discovery within an academic setting.
Post 1 - MEDICINAL CHEMIST: DRUG DISCOVERY UNIT - LS/1636/WWW
The Drug Discovery Unit at the University of Dundee is a £15 million initiative to tackle some of the world’s most neglected diseases, such as African sleeping sickness. The aim of the Unit, the first facility of its kind in Europe, is to translate basic research discoveries into candidate drugs ready for clinical trials. The Unit combines drug discovery expertise from Biotech/Pharma (Director of Drug Discovery and Head of Screening) and the world class basic research into these diseases that is well established at the University. This post is available immediately for 2 years in the first instance.
Post 2 - MEDICINAL CHEMIST: DEVELOPMENT OF NOVEL ANTIMALARIALS - LS/1637/WWW
This post is part of a multi-disciplinary approach to develop new drugs for malaria as part of a European Union consortium. The successful applicant will carry work on optimisation of a series of lead compounds. Work will be carried out in close collaboration with other chemists, molecular modeller, crystallographers, molecular biologists and parasitologists. The post is available immediately for 2 years.
Post 3 - MEDICINAL CHEMIST: DEVELOPMENT OF NOVEL AGENTS FOR TROPICAL DISEASES - LS/1638/WWW
This post is part of a team working on novel agents for the treatment of tropical diseases. The post is available immediately for 1 year.
We are seeking candidates with a PhD in synthetic organic or medicinal chemistry. Subsequent experience, preferably in the pharmaceutical industry would be an advantage.
Salaries will depend on experience.
Informal enquiries should be directed to Professor Ian Gilbert, e-mail: i.h.gilbert@dundee.ac.uk. (DO NOT SEND APPLICATIONS TO THIS ADDRESS).
Applications in the form of a CV and covering letter (2 copies of each), including the names and addresses of 3 referees, should be sent to Human Resources, College of Life Sciences, JBC/MSI/WTB Complex, University of Dundee, DD1 5EH, (HR-LifeSciences@dundee.ac.uk) quoting the relevant reference number.
Applicants will only be contacted if invited for interview
Closing date: 7 February 2007
Post 4 - ASSAY DEVELOPMENT AND HIGH THROUGHPUT SCREENING SCIENTIST - LS/1618/www
A new post has been created as part of an expansion of the Drug Discovery for Tropical Diseases initiative. Available for 2 years in the first instance, this post is located within exceptionally equipped new laboratory facilities in the recently opened Drug Discovery Unit. This post represents a unique opportunity to gain experience in drug discovery within an academic setting. This post will be available from 1 March 2007 and offers a competitive salary.
Candidates are expected to have a PhD in Biochemistry, Pharmacology (or other appropriate Life Science discipline) or have equivalent experience and a keen interest in drug discovery. Previous experience in the Pharmaceutical or Biotechnology industry will be a distinct advantage. This post will involve the development of automated assays, operation of robotics, high volume data handling and interpretation plus regular interaction with a team of world-class tropical disease biochemists, chemists and structural biologists.
Informal enquiries should be directed to Professor J. Frearson, email (j.a.frearson@dundee.ac.uk). (DO NOT SEND APPLICATIONS TO THIS ADDRESS).
Applications in the form of a CV and covering letter (2 copies of each), including the names and addresses of 3 referees, should be sent to Human Resources, College of Life Sciences, JBC/MSI/WTB Complex, University of Dundee, DD1 5EH, (HR-LifeSciences@dundee.ac.uk) quoting LS/1618/www.
Applicants will only be contacted if invited for interview
Closing Date: 9 February 2007
POST 5 - STRUCTURAL BIOLOGIST - LS/1621/SSS
The Drug Discovery Unit at the University of Dundee is a £15 million initiative to tackle neglected diseases and to develop novel drug targets. The Unit is in new and well equipped laboratories in the Biocentre at Dundee, a world-renowned centre for biomedical research including outstanding biology, biochemistry, molecular biology, structural biology, hit discovery, medicinal and computational chemistry, bioinformatics and proteomics groups collaborating on translational research projects
The aim of the Unit, the first of its kind in Europe, is to translate basic research discoveries into candidate drugs ready for clinical trials. The Unit combines drug discovery expertise recruited from Biotech/Pharma with world-class basic research in a number of disease areas.
The appointee will work as a part of a multi-disciplinary team to aid us in our structure-based drug design efforts to identify cures for neglected diseases such as African sleeping sickness. Your main task will be the determination of high-resolution, three-dimensional structures of proteins, covering both de novo structures and protein-ligand complexes. Also, you will assist in exploiting the structural data you generate in the structure-based drug design cycle in close collaboration with computational and medicinal chemists.
The position requires a Ph.D. in structural biology, or life sciences with relevant postdoctoral structural biology experience, preferably in a drug discovery environment. Extensive experience using state-of-the-art crystallographic methods and tools is a must, as is demonstrated creativity in developing rapid solutions to complex research problems. You should have excellent verbal and written communication skills and the ability to work in large, multidisciplinary project-teams. The successful candidate will also have experience in experimental phasing and protein purification/molecular biology. Additional experience of computational chemistry is desirable.
The post represents a unique opportunity to help create a drug discovery unit within an academic setting. This post will be available from 1 March 2007 for 2 years in the first instance. Salary will depend on experience, and will be competitive with those found in the Pharma sector.
Applications in the form of a CV and covering letter (2 copies of each), including the names and addresses of 3 referees, should be sent to Human Resources, College of Life Sciences, JBC/MSI/WTB Complex, University of Dundee, DD1 5EH, (HR-LifeSciences@dundee.ac.uk) quoting LS/1621/www.
Applicants will only be contacted if invited for interview
Closing Date: 16 February 2007
POST 6 - DMPK PHARMACOKINETICIST - LS/1622/WWW
The Drug Discovery Unit at the University of Dundee is a £15 million initiative to tackle some of the world’s most neglected diseases, such as African sleeping sickness. The aim of the Unit, the first facility of its kind in Europe, is to translate basic research discoveries into candidate drugs ready for clinical trials. The Unit combines drug discovery expertise from Biotech/Pharma and the world class basic research into these diseases which is well established at the University.
The Unit is based within the James Black Centre, a new building completed in 2005, part of the University’s internationally respected College of Life Sciences.
A DMPK pharmacokineticist post has been created as part of the discovery project team within the new Unit. Available for 2 years in the first instance, the successful appointee will work as a part of a strong multi-disciplinary drug discovery team. Primary duties include designing, scheduling, monitoring and reviewing in vitro and in vivo DMPK studies and outsourcing to contract organizations as appropriate, managing study timelines, objectives, and budgets, providing practical support for studies as required, interpreting and presenting DMPK study results/project summary and recommendations to project teams, providing scientific and strategic DMPK input into projects, identifying potential hurdles in optimisation of project compounds and objectives, suggesting solutions, and establishing priorities and contingency plans.
Work will be undertaken in both hit to lead and lead optimisation stages of the Drug Discovery Process. The post represents a unique opportunity to help create a successful drug discovery unit within an academic setting and will require excellent team-player and self-starting abilities.
This post will be available from 1 April 2007. Salary will depend on experience, and will be competitive with those found in the Pharma sector.
We are seeking a candidate with a BSc or PhD in natural/biological sciences or equivalent, with a minimum of 4 years experience in drug metabolism and/or pharmacokinetics within a pharmaceutical research & development environment.
Applications in the form of a CV and covering letter (2 copies of each), including the names and addresses of 3 referees, should be sent to Human Resources, College of Life Sciences, JBC/MSI/WTB Complex, University of Dundee, DD1 5EH, (HR-LifeSciences@dundee.ac.uk) quoting LS/1622/www.
Applicants will only be contacted if invited for interview
Closing Date: 16 February 2007
POST 7 - COMPUTATIONAL CHEMIST - LS/1646/www
DEVELOPMENT OF NOVEL ANTIMALARIALS
A post is available within Computational Chemistry at the University of Dundee. This post is based within the James Black Centre, a new building completed in 2005, part of the University’s internationally respected College of Life Sciences.
This post is part of a multi-disciplinary approach to develop new drugs for malaria as part of a European Union consortium. The successful applicant will carry work on optimisation of a series of lead compounds using computational methods. Work will be carried out in close collaboration with chemists, crystallographers, molecular biologists and parasitologists. The post is available immediately for 2 years.
We are seeking candidates with a PhD in molecular modeling applied to drug design. Subsequent experience in this field would be an advantage.
Salary will depend on experience.
Informal enquiries should be directed to Professor Ian Gilbert, e-mail: i.h.gilbert@dundee.ac.uk. (DO NOT SEND APPLICATIONS TO THIS ADDRESS).
Applications in the form of a CV and covering letter (2 copies of each), including the names and addresses of 3 referees, should be sent to Human Resources, College of Life Sciences, JBC/MSI/WTB Complex, University of Dundee, DD1 5EH, (HR-LifeSciences@dundee.ac.uk) quoting LS/1646/www..
Applicants will only be contacted if invited for interview.
Closing date: 9 February 2007